Research Guides: COVID-19 (Coronavirus) Resources: UMD Research

COVID-19 Research @ UMD

This page includes news and resources on COVID-19-related research being conducted by University of Maryland researchers.

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Selected UMD units and researchers involved in coronavirus research

Administrative Units

Current Research at UMD

Below is a sample of research that has been or is currently being conducted by University of Maryland faculty and researchers. This research examines both the novel COVID-19 virus and other infectious viruses like influenza.

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A new national poll conducted by UMD researchers tries to understand American's reactions to coronavirus

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Geographers at the University of Maryland are graphing the spread of the virus across the United States.

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UMCP and UMB researchers are uncovering links between climate, human behavior, and the Covid-19 pandemic.

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Image: Pixaby

A team of researchers from the University of Maryland, Baltimore County and the University of Maryland, College Park received a Rapid Response Research grant from the NSF to investigate increased discrimination in Asian American communities due to the COVID-19 outbreak.

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Picture: Shutterstock.com

In 2019, Dr. Xiaoping Zhu was awarded a $3.1 million NIH grant to create a universal flu vaccine.

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Picture: Center for Disease Control (CDC)

The University of Maryland School of Medicine also received a $200 million dollar NIH grant to develop a universal flu vaccine.

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Picture: C.A.T.C.H. Logo

The Characterizing And Tracking College Health (C.A.T.C.H.) is an ongoing study (through Spring 2020) that seeks to track the spread of flu on college campuses. The study is lead by Dr. Donald Miller, a professor of environmental health, who was recently interviewed in Maryland Today.

Articles on coronaviruses authored by UMD researchers (2004-2018)

Shirvani, E., Paldurai, A., Manoharan, V. K., Varghese, B. P., & Samal, S. K. (2018). A Recombinant Newcastle Disease Virus (NDV) Expressing S Protein of Infectious Bronchitis Virus (IBV) Protects Chickens against IBV and NDV. Scientific Reports, 8(1), 11951.
Abozeid, H. H., Paldurai, A., Khattar, S. K., Afifi, M. A., El-Deeb, A. H., El-Kady, M. F., & Samal, S. K. (2017). Complete genome sequences of two avian infectious bronchitis viruses isolated in Egypt: Evidence for genetic drift and genetic recombination in the circulating viruses. Infection, Genetics and Evolution, 53, 7-14.
Katz, R., Standley, C. J., Kornblet, S., Sorrell, E., Vaught, A., & Fischer, J. E. (2017). Information-Sharing and Disease Reporting in a New Era of International Frameworks and Communication Technology: Middle East Respiratory Syndrome Coronavirus and Ebola Virus Disease Outbreaks (Vol. 5). Singapore: World Scientific Publ Co Pte Ltd.
Gao, F., & Simon, A. E. (2016). Multiple Cis-acting elements modulate programmed-1 ribosomal frameshifting in Pea enation mosaic virus. Nucleic Acids Research, 44(2), 878-895. doi:10.1093/nar/gkv1241
Longhini, A. P., LeBlanc, R. M., Becette, O., Dayie, T. K., Salguero, C., D'Souza, V. M., . . . Johnson, B. A. (2016). Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations. Nucleic Acids Research, 44(6), e52.
Wang, D., Tang, J., Tang, J., & Wang, L.-X. (2015). Targeting N-glycan cryptic sugar moieties for broad-spectrum virus neutralization: progress in identifying conserved molecular targets in viruses of distinct phylogenetic origins. Molecules, 20(3), 4610-4622.
Nan, Y. C., Yu, Y., Ma, Z. X., Khattar, S. K., Fredericksen, B., & Zhang, Y. J. (2014). Hepatitis E Virus Inhibits Type I Interferon Induction by ORF1 Products. Journal of Virology, 88(20), 11924-11932. doi:10.1128/jvi.01935-14
Plant, E. P., Sims, A. C., Baric, R. S., Dinman, J. D., & Taylor, D. R. (2013). Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production. Viruses-Basel, 5(1), 279-294. doi:10.3390/v5010279
Ishimaru, D., Plant, E. P., Sims, A. C., Yount, B. L., Roth, B. M., Eldho, N. V., . . . Hennig, M. (2013). RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus. Nucleic Acids Research, 41(4), 2594-2608. doi:10.1093/nar/gks1361
Belov, G. A., & van Kuppeveld, F. J. M. (2012). (+)RNA viruses rewire cellular pathways to build replication organelles. Current Opinion in Virology, 2(6), 740-747. doi:10.1016/j.coviro.2012.09.006
Dinman, J. D. (2012). Mechanisms and implications of programmed translational frameshifting. Wiley Interdisciplinary Reviews-RNA, 3(5), 661-673. doi:10.1002/wrna.1126
Liao, P. Y., Choi, Y. S., Dinman, J. D., & Lee, K. H. (2011). The many paths to frameshifting: kinetic modelling and analysis of the effects of different elongation steps on programmed-1 ribosomal frameshifting. Nucleic Acids Research, 39(1), 300-312. doi:10.1093/nar/gkq761
Rakauskaite, R., Liao, P.-Y., Rhodin, M. H. J., Lee, K., & Dinman, J. D. (2011). A rapid, inexpensive yeast-based dual-fluorescence assay of programmed-1 ribosomal frameshifting for high-throughput screening. Nucleic Acids Research, 39(14), e97. doi:10.1093/nar/gkr382
Severance, E. G., Dickerson, F. B., Viscidi, R. P., Bossis, I., Stallings, C. R., Origoni, A. E., . . . Yolken, R. H. (2011). Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms. Schizophrenia Bulletin, 37(1), 101-107. doi:10.1093/schbul/sbp052
Dinman, J. D. (2010). Programmed-1 Ribosomal Frameshifting in SARS Coronavirus. New York: Springer.
Patel, D., Nan, Y. C., Shen, M. Y., Ritthipichai, K., Zhu, X. P., & Zhang, Y. J. (2010). Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I Interferon Signaling by Blocking STAT1/STAT2 Nuclear Translocation. Journal of Virology, 84(21), 11045-11055. doi:10.1128/jvi.00655-10
Plant, E. P., Rakauskaite, R., Taylor, D. R., & Dinman, J. D. (2010). Achieving a Golden Mean: Mechanisms by Which Coronaviruses Ensure Synthesis of the Correct Stoichiometric Ratios of Viral Proteins. Journal of Virology, 84(9), 4330-4340. doi:10.1128/jvi.02480-09
Ammayappan, A., Upadhyay, C., Gelb, J., & Vakharia, V. N. (2009). Identification of sequence changes responsible for the attenuation of avian infectious bronchitis virus strain Arkansas DPI. Archives of Virology, 154(3), 495-499. doi:10.1007/s00705-009-0325-9
Ammayappan, A., & Vakharia, V. N. (2009). Complete Nucleotide Analysis of the Structural Genome of the Infectious Bronchitis Virus Strain Md27 Reveals its Mosaic Nature. Viruses-Basel, 1(3), 1166-1177. doi:10.3390/v1031166
Jakupciak, J. P., & Colwell, R. R. (2009). Biological agent detection technologies. Molecular Ecology Resources, 9, 51-57. doi:10.1111/j.1755-0998.2009.02632.x
Ammayappan, A., Upadhyay, C., Gelb, J., & Vakharia, V. N. (2008). Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination. Virology Journal, 5, 7. doi:10.1186/1743-422x-5-157
Plant, E. P., & Dinman, J. D. (2008). The role of programmed-1 ribosomal frameshifting in coronavirus propagation. Frontiers in Bioscience, 13, 4873-4881. doi:10.2741/3046
Severance, E. G., Bossis, I., Dickerson, F. B., Stallings, C. R., Origoni, A. E., Sullens, A., . . . Viscidi, R. P. (2008). Development of a Nucleocapsid-Based Human Coronavirus Immunoassay and Estimates of Individuals Exposed to Coronavirus in a US Metropolitan Population. Clinical and Vaccine Immunology, 15(12), 1805-1810. doi:10.1128/cvi.00124-08
DiNapoli, J. M., Kotelkin, A., Yang, L., Elankumaran, S., Murphy, B. R., Samal, S. K., . . . Bukreyev, A. (2007). Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens. Proceedings of the National Academy of Sciences of the United States of America, 104(23), 9788-9793. doi:10.1073/pnas.0703584104
Plant, E. P., & Dinman, J. D. (2006). Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systems. RNA, 12(4), 666-673. doi:10.1261/rna.2225206
Plant, E. P., Perez-Alvarado, G. C., Jacobs, J. L., Mukhopadhyay, B., Hennig, M., & Dinman, J. D. (2005). A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal. PLoS Biol, 3(6), e172.
Jacobs, J. L., & Dinman, J. D. (2004). Systematic analysis of bicistronic reporter assay data. Nucleic Acids Research, 32(20), e160/161-e160/110. doi:10.1093/nar/gnh157